|
| From | Destination | Airline |
|---|
| Cayman Brac (CYB) | Denver, CO (DEN) | Cayman Airways (Non-Direct) |
| Grand Cayman (GCM) | Atlanta, GA (ATL) | Delta Air Lines (Direct) |
| Grand Cayman (GCM) | Baltimore, MD (BWI) | Southwest Airlines (Direct) |
| Grand Cayman (GCM) | Charlotte, NC (CLT) | American Airlines (Direct) |
| Grand Cayman (GCM) | Dallas/Ft. Worth, TX (DFW) | American Airlines (Direct) |
| Grand Cayman (GCM) | Denver, CO (DEN) | Cayman Airways (Direct) |
| Grand Cayman (GCM) | Dulles, Washington, DC (IAD) | United Airlines (Direct) |
| Grand Cayman (GCM) | Edward L. Logan, Boston, MA (BOS) | JetBlue Airways (Direct) |
| Grand Cayman (GCM) | Fort Lauderdale, FL (FLL) | Southwest Airlines (Direct) |
| Grand Cayman (GCM) | George Bush, Houston, TX (IAH) | United Airlines (Direct) |
| Grand Cayman (GCM) | John F. Kennedy, New York, NY (JFK) | Cayman Airways (Direct)
JetBlue Airways (Direct) |
| Grand Cayman (GCM) | Los Angeles, CA (LAX) | Cayman Airways (Direct) |
| Grand Cayman (GCM) | Miami, FL (MIA) | American Airlines (Direct)
Cayman Airways (Direct) |
| Grand Cayman (GCM) | Minneapolis/Saint Paul, MN (MSP) | Delta Air Lines (Direct)
Sun Country (Direct) |
| Grand Cayman (GCM) | Newark Liberty, New York, NY (EWR) | United Airlines (Direct) |
| Grand Cayman (GCM) | O'Hare, Chicago, IL (ORD) | American Airlines (Direct)
United Airlines (Direct) |
| Grand Cayman (GCM) | Orlando, FL (MCO) | Southwest Airlines (Direct) |
| Grand Cayman (GCM) | Philadelphia, PA (PHL) | American Airlines (Direct) |
| Grand Cayman (GCM) | Tampa, FL (TPA) | Cayman Airways (Direct) |